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EIGHT TWENTY ONE PROTEIN
Descriptors Found:
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DeCS
Descriptor
English
:
RUNX1 Translocation Partner 1 Protein
Descriptor
Spanish
:
Proteína 1 Compañera de Translocación de RUNX1
Descriptor
Portuguese
:
Proteína 1 Parceira de Translocação de RUNX1
Synonyms
English
:
Eight Twenty One Protein
RUNX1T1 Protein
Tree Number:
D12.776.624.664.700.936
D12.776.930.780.625.575
Definition
English
:
A transcriptional co-repressor that contains a MYND-type zinc
finger
(MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding
transcription factors
, other
repressor proteins
, and
HISTONE ACETYLTRANSFERASES
to repress expression of genes involved in cell
growth
and differentiation such as
MATRIX METALLOPROTEINASE 7
and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and
CORE BINDING FACTOR ALPHA 2 SUBUNIT
(RUNX1) genes frequently occurs in cells of
leukemia
patients
; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
History Note
English
:
2018
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
57141
Unique Identifier:
D000075142
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS